If you’ve got relentless nausea, awful motion sickness, or allergy symptoms that won’t quit, your clinician might reach for Promethazine. It works-and it can knock you out. That trade-off is the whole story: relief versus drowsiness and a few serious safety rules. This guide explains when to use it, how to dose it safely, who should skip it, and what to consider instead. I’ll keep it practical and up-to-date for 2025.
Jobs you likely want to get done right now:
- Figure out what promethazine actually treats and how fast it works.
- Know the right dose and route (pill, liquid, suppository, injection) for adults and kids.
- Avoid nasty side effects and risky interactions (opioids, alcohol, benzos, etc.).
- Decide if a non-sedating alternative is smarter for your situation.
- Have a simple plan for travel, pregnancy nausea, or a sick kid (age 2+).
TL;DR
- Promethazine is a sedating antihistamine used for nausea/vomiting, motion sickness, allergy symptoms, and short-term sedation. It can make you very sleepy.
- Boxed warnings: never use in kids under 2; avoid IV push and intra-arterial injection due to severe tissue injury risk; use IM if injectable is needed.
- Common side effects: drowsiness, dizziness, dry mouth, constipation, blurred vision. Serious but rare: breathing problems, severe tissue injury, heart rhythm issues, seizures, dystonia.
- Big interactions: alcohol, opioids, benzodiazepines, sleep meds, and other anticholinergics. Don’t drive until you know how it affects you.
- Often-better options: ondansetron for nausea; cetirizine/loratadine for allergies; meclizine for motion sickness; doxylamine-pyridoxine in pregnancy.
What it treats, how it works, and when it makes sense
Promethazine is a first-generation antihistamine with strong anticholinergic and antiemetic effects. In plain English: it blocks histamine and calms the brain’s nausea center. That’s why it helps with motion sickness, vertigo-related nausea, and vomiting from many causes. It also dries up a runny nose and eases sneezing, but newer non-sedating antihistamines do that with far less drowsiness.
Common reasons it’s prescribed:
- Nausea and vomiting (post-op, migraine-related, gastroenteritis-when fluids can be kept down).
- Motion sickness prevention and treatment.
- Allergy symptoms (itchy, runny nose; sneezing), though it’s not first-line for daytime use because of sedation.
- Short-term nighttime sedation when symptoms are miserable and rest is needed.
Realistic expectations:
- It often works within 20-60 minutes by mouth; suppositories can help when you can’t keep pills down.
- It’s sedating by design. If you need to be sharp for work or driving, consider alternatives.
- It’s not a cure for the underlying cause of nausea or allergies. Treat the cause when possible.
“Promethazine is contraindicated in pediatric patients less than 2 years of age because of the potential for fatal respiratory depression.” - U.S. FDA Prescribing Information (Boxed Warning)
Safe dosing and how to take it (adults and kids 2+)
Forms you’ll see: tablets (12.5 mg, 25 mg, 50 mg), oral syrup (6.25 mg per 5 mL), rectal suppositories (12.5/25/50 mg), and injections (hospital use; IM preferred).
| Indication | Typical Adult Dose | Route | Onset | Duration | Notes |
|---|---|---|---|---|---|
| Nausea/Vomiting | 12.5-25 mg every 4-6 hours as needed | Oral or rectal | 20-60 min | 4-12 hours | Start low if sensitive to sedation |
| Motion Sickness (prevention) | 25 mg taken 30-60 min before travel; may repeat in 8-12 hours | Oral | 30-60 min | Up to 12 hours | Test a “home dose” first for drowsiness |
| Allergic Rhinitis | 12.5-25 mg at bedtime; some take 12.5 mg 2-3× daily | Oral | 20-60 min | 4-12 hours | Prefer non-sedating antihistamines daytime |
| Pre-/Post-op Sedation (clinical) | 12.5-25 mg | IM (preferred in clinical settings) | Rapid | Varies | IV and intra-arterial routes carry serious tissue injury risk |
Pediatric dosing (age 2+ only): clinicians often use weight-based dosing. A common range is 0.25-1 mg/kg per dose every 4-6 hours as needed (max per dose usually 25 mg), but exact dosing depends on the condition and the child’s risk factors. Always have a clinician calculate and confirm the dose for kids.
How to take it right:
- Tablets: swallow with water; food can ease stomach upset. If you feel too drowsy, ask about taking a smaller dose.
- Liquid: use a metric syringe or dosing spoon-never a kitchen spoon. Shake well.
- Suppository: unwrap, moisten the tip, lie on your side, insert gently into the rectum pointed end first. Hold cheeks together for a few seconds to keep it in place.
- Timing for travel: take 30-60 minutes before motion. For long trips, many people take a single bedtime dose the night before to test how sleepy they get.
- Hydration: if you’re vomiting, take tiny sips of clear fluids every 5-10 minutes. When you can keep 8-16 ounces down, try light food.
Pregnancy: for nausea and vomiting of pregnancy, doxylamine-pyridoxine is first-line. Promethazine is used when symptoms are not controlled, usually short-term and at the lowest effective dose. Discuss risks (sedation, anticholinergic effects) with your obstetric clinician.
Side effects, red flags, and who should avoid it
Common effects (often dose-related):
- Drowsiness, dizziness, impaired coordination; “hangover” the next day.
- Dry mouth, constipation, blurred vision, urinary retention.
- Low blood pressure, especially when standing up fast (orthostasis).
Less common but serious-get help fast if you notice:
- Breathing problems, extreme sleepiness, confusion-especially in kids, older adults, or with other sedatives.
- Severe tissue injury with injection: burning pain, blisters, discoloration; avoid IV/intra-arterial use.
- Heart rhythm changes (fast or irregular heartbeat, fainting).
- Seizures or severe muscle spasms/stiffness (acute dystonia).
- Jaundice (yellowing skin/eyes), fever with sore throat (possible blood issues), or very high fever and muscle rigidity (rare neuroleptic malignant syndrome).
Who should avoid or use with caution:
- Children under 2 years: contraindicated (risk of fatal respiratory depression).
- People with severe asthma, lower respiratory tract symptoms, sleep apnea, or severe COPD: higher risk of breathing problems.
- Elderly adults: high on Beers Criteria for anticholinergic burden and falls; use only if benefits clearly outweigh risks.
- Glaucoma, enlarged prostate, urinary retention, bowel obstruction: anticholinergic effects can worsen symptoms.
- Seizure disorders: phenothiazines may lower seizure threshold.
- Liver disease: dose adjustments and close monitoring may be needed.
- Coma or concurrent MAO inhibitor use: avoid.
Allergy testing note: antihistamines can blunt skin test results. Most clinics ask you to stop promethazine 72 hours before testing-confirm with your allergist.
Interactions and smarter alternatives (decision guide)
Major interactions that amplify sedation and breathing risk:
- Alcohol, opioids (e.g., oxycodone, hydrocodone, morphine), benzodiazepines (e.g., lorazepam), sleep aids (zolpidem), gabapentinoids.
- Other anticholinergics (e.g., oxybutynin, tricyclic antidepressants): more dry mouth, constipation, blurry vision, urinary retention.
- Metoclopramide and other dopamine blockers: higher risk of dystonia and Parkinsonian side effects.
- Blood pressure meds: additive hypotension and lightheadedness.
- Epinephrine for hypotension after overdose/excess use of phenothiazines is not advised; norepinephrine or phenylephrine is preferred in clinical settings per labeling.
Safer or more targeted alternatives by symptom:
- Nausea/vomiting: ondansetron (less sedating, great for many causes), prochlorperazine (also sedating; watch for EPS), dimenhydrinate/meclizine for motion sickness.
- Motion sickness: meclizine works well with milder sedation; scopolamine patch for multi-day trips.
- Allergies: cetirizine, levocetirizine, loratadine, or fexofenadine for daytime relief with minimal drowsiness; intranasal steroids (fluticasone, triamcinolone) for strong control.
- Pregnancy nausea: doxylamine-pyridoxine first-line; add ondansetron or promethazine under obstetric guidance if needed.
Quick decision tips:
- If staying alert matters (work, driving), pick ondansetron for nausea or a non-sedating antihistamine for allergies.
- If vomiting keeps you from swallowing pills, a promethazine suppository can be useful short-term.
- If you’re already on opioids, avoid promethazine unless your clinician says the benefit outweighs the added breathing risk.
- Older adults: try non-sedating options first. If you do use promethazine, lowest dose, bedtime only, and fall precautions.
Real-world use: scenarios, checklists, and what to watch for
Scenario 1: You have a long flight and get motion sick. You take 25 mg 60 minutes before boarding, drink water, and skip alcohol. You feel drowsy but stable. If you need a second dose, you wait 8-12 hours. You don’t drive after landing-rideshare instead.
Scenario 2: You have a stomach bug with nonstop vomiting. Your clinician prescribes a 25 mg suppository every 6 hours as needed. You use small sips of oral rehydration solution and progress to bland food once vomiting slows. You switch to oral meds as soon as you can keep fluids down.
Scenario 3: Your seasonal allergies are wrecking your sleep. You try 12.5 mg at bedtime for a few nights while starting an intranasal steroid. You use cetirizine in the daytime. Once the nasal steroid kicks in (a few days), you taper off promethazine.
Pre-use checklist:
- Any diagnosis of sleep apnea, COPD, glaucoma, urinary retention, seizure disorder, or liver disease?
- Any use of alcohol, opioids, benzos, sleep meds, or other sedating drugs?
- Need to drive, operate machinery, or make big decisions in the next 12 hours?
- Under age 2? Stop-do not use.
First-dose plan:
- Start at the low end (12.5-25 mg in adults).
- Take when you have time to monitor drowsiness. Avoid alcohol.
- Hydrate and stand up slowly to reduce lightheadedness.
When to call a clinician urgently:
- Breathing gets slow or shallow, extreme sleepiness, or unresponsiveness.
- Severe confusion, agitation, muscle spasms, or a seizure.
- Severe arm pain/discoloration after any injection.
- New chest pain, fainting, or very fast/irregular heartbeat.
Documentation backing this guidance: FDA Prescribing Information carries the boxed warnings and route restrictions; the American Geriatrics Society Beers Criteria flags strong anticholinergics like promethazine as high-risk in older adults; obstetric care commonly prioritizes doxylamine-pyridoxine first for pregnancy nausea, with ondansetron or promethazine as add-ons when needed.
FAQ and next steps
Can I take promethazine with ondansetron? Yes, clinicians sometimes combine them for severe nausea. Watch for extra sedation from promethazine and constipation from both. Space them out by at least an hour if possible.
Is promethazine the same as Phenergan? Phenergan is a brand name for promethazine in some regions. The safety warnings and dosing are the same.
Will it help with cough? It may calm a nighttime cough because it dries secretions and sedates, but it’s not a cough cure. In children, cough/cold combinations are discouraged. For adults, weigh sedation risk and try non-drug measures first.
How long can I take it? It’s usually for short-term use-days, not weeks. If you need it longer, your clinician should reassess the cause and check safer alternatives.
Can I drink alcohol with it? No. Alcohol greatly increases sedation and breathing risks.
Does it affect heart rhythm? It can prolong QT in some people. If you have a history of QT prolongation, are on other QT-prolonging drugs, or have electrolyte issues, tell your clinician.
What if I miss a dose? For scheduled use (rare outside clinical settings), take it when you remember unless it’s close to the next dose. Don’t double up.
Next steps by situation:
- Traveler: test a 12.5-25 mg dose at home before your trip. Pack non-sedating backups (meclizine or scopolamine if advised) and hydrate.
- Pregnancy: ask your obstetric clinician about doxylamine-pyridoxine first. If using promethazine, use the lowest effective dose and consider bedtime dosing.
- Parent (child 2+): get a weight-based dose from your pediatrician. Use a metric syringe for liquid. Never for kids under 2 years.
- Older adult: if you must use it, go low, go slow, and favor bedtime only. Fall-proof your space and avoid alcohol.
If you’re still unsure whether promethazine is right for you, use this simple rule: if alertness and breathing safety are top priorities, reach for a non-sedating option. If vomiting is relentless and you need strong relief quickly, a short course of promethazine-at the lowest effective dose and away from alcohol or other sedatives-can be reasonable under your clinician’s guidance.
vanessa parapar
September 19, 2025 AT 18:23Promethazine is basically the grandpa of antihistamines-effective but old-school. I’ve seen people take it for nausea and wake up three hours later wondering why their couch is a hammock. If you’re not sleeping, you’re not taking enough. But seriously, don’t mix it with anything that makes you drowsy. I once saw a guy try to drive after a suppository. He ended up in a ditch. Not proud of him. Or the ditch.
And yes, kids under two? Absolutely no. FDA didn’t make that warning because they hate fun. They made it because someone’s baby died. Learn from the dead.
For allergies? Just take loratadine. It’s like promethazine’s chill cousin who doesn’t knock you into a coma. Save the heavy artillery for when you’re vomiting into a bucket.
Also, the suppository instructions? Perfect. I wish more medical guides had that level of detail. Moistening the tip? Genius. I didn’t know you had to treat it like a little medical burrito.
And no, alcohol with this? That’s not a cocktail. That’s a suicide pact with a side of dizziness.
TL;DR: Use it. But like, respectfully. And never alone in a car.
Also, why is this still a thing when ondansetron exists? Because insurance.
And yes, I’m a pharmacist. You’re welcome.
Ben Wood
September 20, 2025 AT 01:43Let me be perfectly clear: promethazine is a pharmacological relic, a relic that, despite its efficacy, should be relegated to the museum of outdated medical practices-along with leeches and bloodletting. The fact that we still prescribe it for motion sickness, when meclizine and scopolamine patches are available, is a testament to the inertia of medical tradition-and the pharmaceutical industry’s reluctance to phase out cheap generics.
Moreover, the IV route? Unforgivable. Even in clinical settings, the risk of tissue necrosis is not a ‘possible’ side effect-it’s a guaranteed catastrophe waiting to happen if the clinician isn’t paying attention. And yet, I’ve seen it done. In a rural ER. By someone who ‘didn’t know any better.’
And let’s not pretend the sedation is ‘by design.’ It’s a side effect that’s so severe it renders the drug unusable for any functional adult. If you need to be sedated, take a benzo. Don’t mask it under a 1950s antihistamine with anticholinergic baggage.
Also, the FDA warning is not a suggestion. It’s a legal mandate. And yet, I’ve seen parents give it to toddlers ‘because it worked for their cousin.’
There is no excuse. Not one.
And if you’re using it for allergies, you’re doing it wrong.
End of rant.
Sakthi s
September 20, 2025 AT 12:52Good guide. Simple, clear, no fluff.
Use it when you need it.
Don’t use it when you don’t.
Stay safe.
Rachel Nimmons
September 21, 2025 AT 15:52Did you know promethazine was originally developed as a sedative for psychiatric patients in the 1940s? And that it was later repurposed because the drug companies realized they could market it for ‘motion sickness’ and ‘allergies’-two conditions that don’t require sedation? There’s a reason it’s still on the market. It’s not because it’s safe. It’s because it’s cheap. And because the FDA doesn’t have the resources to pull every dangerous drug off the shelves.
Also, have you ever read the full clinical trial data? The one where 17% of patients had ‘significant cognitive impairment’ lasting over 24 hours? That’s not ‘drowsiness.’ That’s brain fog with a side of existential dread.
And don’t get me started on the ‘suppository’ route. Why is that even an option? Who approved that? Who decided that putting a drug up your butt was acceptable for nausea?
I’m not saying don’t use it. I’m saying: if you do, you’re part of a system that lets dangerous drugs stay on shelves because they’re profitable.
Just sayin’.
Abhi Yadav
September 22, 2025 AT 09:01promethazine is the silent assassin of the nervous system
it doesn't kill you fast
it kills your will to move
your thoughts
your joy
you wake up and forget why you were even trying
and that's the real danger
not the box warning
the quiet erosion of self
we take it for nausea
but it takes more than nausea
it takes your presence
your light
your tomorrow
and gives you back a zombie version of you
and we call that treatment
what a joke
we're all just trying to sleep through the pain
but maybe the pain is the only thing keeping us alive
just saying
maybe the answer isn't more drugs
but more stillness
more breath
more not fixing
just being
and if you're still reading this
you're already halfway there
Julia Jakob
September 22, 2025 AT 16:31okay so i took promethazine once for a migraine and i swear i thought i was in a dream for 12 hours
like i was floating in a warm bath of syrup and someone had turned off the sound
my cat was meowing but i couldn't hear it
my phone was buzzing but i didn't move
my brain just said 'nah, we're done today'
and then i woke up and realized i'd left the oven on
and i didn't even remember turning it on
so yeah
it works
but it doesn't just knock you out
it deletes you
for a while
also
why is this still a thing
like we have ondansetron now
and it doesn't make you forget your own name
also
why is the suppository thing so normal
like who decided this was acceptable
who signed off on 'insert butt medicine'
who approved this
who are we
what is life
why am i typing this at 3am
why am i still awake
why is my dog staring at me
did i take it again
am i still on it
help
Robert Altmannshofer
September 23, 2025 AT 12:39Man, this is one of those posts that reminds me why I love this subreddit.
Clear, practical, no fluff. Just the facts wrapped in real talk.
I’ve used promethazine for post-op nausea after a big surgery-25mg suppository. Worked like a charm. Didn’t feel like a zombie, just deeply relaxed. Took it at night. No alcohol. No driving. No drama.
But here’s the thing: I’ve also seen friends use it like candy. ‘Oh, I’m just gonna take one for my allergies.’ And then they’re nodding off at their desk. Or trying to drive. Or worse-mixing it with their nightly wine.
It’s not a ‘mild’ drug. It’s a heavy hitter. Treat it like a chainsaw, not a butter knife.
And for parents: if your kid’s under two, don’t even think about it. I’ve seen the ER reports. It’s not worth the risk.
For everyone else? Use it wisely. Use it sparingly. Use it with respect.
And if you’re looking for alternatives? Ondansetron for nausea. Cetirizine for allergies. Meclizine for motion sickness. All better options for most people.
Thanks for writing this. Needed this today.
Kathleen Koopman
September 24, 2025 AT 02:58so i just took promethazine for the first time and it’s like my brain went on vacation 🌴💤
not bad vacation, just… very chill vacation
like i sat on the couch and stared at the wall for an hour and felt perfectly okay with it
my cat judged me but i didn’t care 😌
also the suppository thing? weird but i get it
if you can’t keep anything down, you gotta go where it sticks 😅
still gonna stick with ondansetron for nausea tho
because i like being awake
and also i don’t want to forget my own birthday
🧠➡️🧠💤
thanks for the guide!!
Nancy M
September 25, 2025 AT 10:36As a medical professional with over two decades of experience in global health systems, I must commend the clarity and precision of this guide. It reflects a commendable effort to bridge the gap between clinical knowledge and public understanding.
That said, the widespread use of promethazine in low-resource settings remains a concern. In many developing nations, it is often the only antiemetic available, and its misuse-particularly in pediatric populations-is tragically common due to lack of education and access to alternatives.
The boxed warnings are not merely bureaucratic formalities; they are ethical imperatives. I have witnessed the consequences of IV promethazine administration in untrained hands. The tissue necrosis is not just painful-it is disfiguring, lifelong.
Education, not restriction, is the true solution. This guide is a step in that direction.
Thank you for writing it.
gladys morante
September 25, 2025 AT 12:20I took this for nausea and now I can’t remember why I was even sick.
Also I think my neighbor is spying on me.
Why do they always come at night?
And why is the fridge so loud?
I think they’re using the suppository to track me.
It’s not just for nausea.
It’s a government tool.
I read it in a forum.
Someone said.
They said it’s in the water.
They said it’s in the pills.
They said they put it in the suppositories to make people forget.
And now I forget why I’m scared.
But I’m scared.
Why is the light blinking?
Did I take it again?
Is this real?
Help.
Precious Angel
September 27, 2025 AT 05:16Let me tell you something, because I’ve been there-I’ve been the one vomiting in the bathroom, shaking, desperate, and then some doctor hands me this little white pill and says ‘it’ll help’-and I believed them.
But here’s the truth they don’t tell you: promethazine doesn’t just sedate you. It erases you. For hours. For days. You lose chunks of time. You forget your own voice. You stare at the ceiling and wonder if you’re still alive or if you died and no one told you.
And then you find out your child was given it for a cold-and you scream. You scream because you know what it did to you. And now it’s doing it to them.
And the doctors? They don’t care. They’re paid by the system. The system wants you sedated. Quiet. Docile. Because a sedated patient is an easy patient.
And the suppository? That’s not medicine. That’s humiliation dressed in sterile packaging.
And the FDA? They’re just the face of the machine.
They let it stay on the shelves because they don’t want to admit they made a mistake.
So now you’re reading this. And you’re wondering if you should take it.
Don’t.
Don’t take it.
Not for nausea.
Not for allergies.
Not for motion sickness.
Not even if you’re dying.
Because if you take it, you’re not healing.
You’re surrendering.
And they win.
They always win.
Melania Dellavega
September 27, 2025 AT 20:13I used to think promethazine was just a sleepy pill.
Then I used it during a really bad pregnancy nausea episode.
It didn’t just make me sleepy-it made me feel like I was wrapped in a warm blanket while the world outside kept spinning.
It didn’t fix the nausea.
But it gave me the peace to breathe through it.
And sometimes, that’s enough.
Not because it’s perfect.
But because sometimes, healing isn’t about being sharp.
It’s about being still.
And if you’re in pain, and you need stillness…
Maybe that’s not weakness.
Maybe that’s survival.
Just don’t mix it with alcohol.
And don’t drive.
And for the love of everything holy-never give it to a toddler.
That part? Non-negotiable.
Bethany Hosier
September 28, 2025 AT 07:10According to the U.S. Food and Drug Administration’s 2025 revised pharmacovigilance bulletin, promethazine’s association with QT prolongation has been statistically re-evaluated in a meta-analysis of 12,347 patients, revealing a 2.7% incidence rate in individuals with pre-existing electrolyte imbalances. Furthermore, the 2024 American Academy of Pediatrics update explicitly prohibits its use in children under the age of 24 months, citing a 17-fold increase in mortality risk compared to alternative antiemetics. The manufacturer’s labeling, while legally compliant, remains insufficiently transparent regarding the cumulative anticholinergic burden in geriatric populations, particularly when co-administered with selective serotonin reuptake inhibitors. I recommend consulting the FDA’s MedWatch portal for adverse event reports filed in Q1 2025, which indicate a 43% increase in emergency department visits related to promethazine misuse in the Midwest region. Please, for the sake of public safety, do not underestimate this medication.
Krys Freeman
September 28, 2025 AT 22:44Why are we even talking about this? America’s got better drugs. We don’t need 1950s junk. If you can’t afford ondansetron, get a job. Or move to Canada. Or something. This is why our healthcare sucks-because we still use this crap.
Shawna B
September 29, 2025 AT 21:01so i took one and slept for 8 hours
woke up fine
no vomit
no dizzy
just sleepy
good enough
Jerry Ray
October 1, 2025 AT 01:27They say avoid alcohol but I did it once and I was fine
They say don't use in kids under 2 but my cousin did and her kid is fine
They say don't inject it but my uncle did and he didn't die
They say it's dangerous but I'm still here
So maybe the warnings are just fear-mongering
Maybe you're overreacting
Maybe you're just scared of what works
Maybe you're the problem
David Ross
October 1, 2025 AT 14:20It is imperative that the public be made aware that promethazine hydrochloride, a phenothiazine derivative, possesses pharmacological properties that are not only anticholinergic and antihistaminic, but also possess significant dopamine receptor antagonism, thereby rendering it potentially neurotoxic in susceptible populations. The FDA’s boxed warning, while legally binding, does not adequately convey the magnitude of risk associated with its off-label use in pediatric populations, particularly in the context of concurrent respiratory infections. Moreover, the routine use of rectal administration in ambulatory settings represents a profound failure of clinical judgment and patient education. This is not medicine. This is negligence dressed in pharmaceutical packaging. I have reviewed the clinical trial data. I have seen the autopsy reports. I have spoken to the families. Do not underestimate this drug. It is not a remedy. It is a risk. A calculated, institutionalized risk. And you are paying for it.
Sophia Lyateva
October 3, 2025 AT 05:54i think they put promethazine in the water supply to keep people quiet
they don't want us thinking too much
that's why it makes you sleepy
that's why the suppository thing is so weird
they want us to forget
and if you take it
you're helping them
and if you don't take it
they'll find another way
they always do
they're watching
and they're waiting
and they're never wrong
so don't take it
even if you think you need it
they're already inside you
vanessa parapar
October 3, 2025 AT 12:23Wow, you actually took it for a migraine? That’s wild. I’ve only seen it used for nausea or allergies. But now I’m wondering if it’s a hidden migraine hack. I’ve got a buddy who swears by it for cluster headaches. Says it’s like hitting a reset button on his brain.
Still, I’d never try it without testing the drowsiness first. I once took a 25mg dose on a Saturday morning and ended up missing my own birthday party. My dog had more fun than I did.
Also, the suppository thing? Still weird. But honestly? If you’re puking and can’t swallow, it’s the only thing that works. I’ve seen it save people in the ER. No joke.
And yeah, the government conspiracy stuff? Nah. But the pharma profit motive? 100%. That’s real.
Robert Altmannshofer
October 3, 2025 AT 13:15That’s actually a really good point about migraines. I’ve seen neurologists use it off-label for refractory migraines with nausea-especially when triptans fail. It’s not first-line, but when you’re in that kind of pain and vomiting, sometimes you need the heavy guns.
And yeah, the ‘reset button’ analogy? Spot on. It doesn’t fix the migraine. It just gives your brain a break from the storm.
Still, I’d never recommend it unless you’ve got a solid plan: take it at night, no driving, no mixing, and know your limits.
It’s not a miracle. But it’s a tool. And tools can be dangerous if you don’t know how to use them.